John Wayne Casserole with Bisquick (Cattle Drive Casserole)
This easy casserole recipe is filled with layers of ground beef with taco seasoning, green peppers, onions and a sour-cream based cheesy sauce, topped with cheddar cheese.The layers sit on top of a delicious biscuit crust. John Wayne Casserole is a sensational recipe and exactly what you need for a busy weeknight dinner.
If you love this recipe, add our Cowboy Cornbread Casserole, Chicken Enchilada Casserole and Beef Enchilada Casserole and Mexican Chicken Casserole to your meal plan!
Want to save this recipe?
Enter your email below & we’ll send it straight to your inbox. Plus you’ll get great new recipes from us every week!
Cattle Drive Casserole
Why we love John Wayne Casserole
- satisfying comfort food that the whole family enjoys, and it’s delicious leftover too!
- simple ingredients that can be found in the local grocery store.
- like my Dorito Chicken Casserole recipe, it’s perfect for a busy weeknight. What weeknight isn’t busy right? I know you’re thinking that and I feel ya!
Try these easy casserole recipes next!
Cheesy Chicken Tater Tot Casserole Recipe
Philly Cheesteak Casserole with Ground Beef Recipe
Old-Fashioned Tuna Noodle Casserole
Green Bean Tater Tot Casserole
Million Dollar Chicken Casserole
What is John Wayne Casserole
The original version and history of this casserole was created by John Wayne! John Wayne contributed the recipe to a cookbook titled, “Cooking with Love from Cara and Her Friends”, compiled by a Cara Connery. I’ve adapted this recipe from the orginal and I will suggest some variations, however it is delicious as written in the original format.
I must digress for a moment and age myself as I fondly recall rainy Sunday afternoons as a young girl watching John Wayne movies with my Dad. Anyone else old enough to relate?
If you love casserole recipes, then you’ve gotta try my Philly Cheesesteak Casserole Next. It has a similar biscuit crust but the other flavors are completely different and delicious!
If you prefer a classic, old-fashioned casserole recipe, try my old-school tuna noodle casserole recipe with potato chips!
Ingredients & Substitutions
- Ground Beef – you can also substitute ground turkey for the ground beef.
- Taco seasoning – use the packaged taco seasoning that you find in the grocery store or, if you make a lot of taco recipes, try my homemade taco seasoning recipe and use 2 to 3 Tablespoons for this recipe. It’s great to have on hand and keeps for six months.
- Sour cream – full fat sour cream is delicious in this recipe or you can use light or reduced-fat sour cream.
- Mayonnaise – use your favorite brand.
- Sharp cheddar cheese – we like sharp cheddar or you can use mild, medium cheddar, pepper jack cheese or Monterey Jack cheese. Or a combination of those or whatever you have in the fridge!
- Green bell peppers – or substitute with yellow, orange or red bell peppers.
- Onion – I use yellow cooking onions. Sweet Vidalia onions are a great second choice.
- Bisquick mix
- Canned tomatoes – you can sub in two to three small sliced tomatoes for the canned tomatoes.
- Can of green chiles
Step by step instructions – How to make John Wayne Casserole
You can find a full printable recipe card at the bottom of this page with a detailed ingredients list and instructions. I’ve included a few photos below with some visual photos to help you along the way with this cheesy casserole recipe.
STEP ONE – Preheat oven to 350°F. Grease a 9×13-inch casserole dish.
PREPARE THE BISCUIT LAYER
Let’s get started with this biscuit casserole and start with the biscuit crust.
STEP TWO – In a large bowl, combine water and biscuit mix. Give it one minute to sit and thicken up a little.
STEP THREE- Spread the biscuit dough into the bottom of the prepared 9×13-inch casserole dish.
STEP FOUR – In a large skillet, brown ground beef over medium-high heat until browned. Stir in taco seasoning and add water according to directions on taco seasoning. (usually 1/4 to 1/2 cup of water).
Spread the meat mixture on top of the biscuit layer.
STEP FIVE – Drain the canned tomatoes, then spread the tomatoes on top of the ground beef.
STEP SIX – In the same skillet, cook the green pepper and sliced onions until softened over medium heat for about 5 minutes. Sprinkle this mixture on top of the tomatoes and ground beef mixture, followed by the can of green chiles.
STEP SEVEN – In a small bowl, combine sour cream, mayonnaise and 1/2 of the shredded cheese. Spread on top of the beef mixture.
STEP EIGHT – Top with remaining cheese and bake in 350°F oven for 30 minutes. Let rest five minutes before serving.
What to serve with cowboy casserole
If you’re serving a crowd and looking for easy side dishes to serve with John Wayne Casserole, then try these easy side dishes:
Paula Deen’s Corn Casserole with Cheese
Green Bean Casserole with Sour Cream
Easy Cheesy Scalloped Potatoes
And for dessert, how about Laura Bushs’s award-winning Cowboy Cookies! Sign me up!!
Storage instructions
Cool casserole, then wrap casserole dish with plastic wrap, or carefuly transfer to an airtight container. Refrigerate for up to three days.
Reheating instructions
Reheat leftover casserole by cooking in 350°F oven until heated through. This should take about 20 minutes. Individual portions can be reheat in the microwave for one to two minutes.
Can you freeze John Wayne Casserole?
Yes! This casserole freezes and reheats well. Cook casserole completely, then cool. Wap entire casserole dish in plastic wrap followed by a layer of aluminum foil. Freeze for up to three months. Thaw completely in the refrigerator, then reheat in 350°F oven until heated though.
I would love it if you left a comment about this recipe below! Subscribe to join the community and receive regular updates straight to your inbox! Let’s connect via Facebook, Instagram & Pinterest!
Print
John Wayne Casserole with Bisquick
- Total Time: 45 minutes
- Yield: 6 to 8 servings
Description
This easy casserole recipe is filled with layers of ground beef with taco seasoning, green peppers, onions and a sour-cream based cheesy sauce topped with cheddar. The layers sit on top of a delicious biscuit crust. John Wayne Casserole is a great recipe and exactly what you need for a busy weeknight dinner.
Ingredients
2 cups Bisquick baking mix (mixed with 1 cup water)
2 pounds ground beef
1 packet taco seasoning
1 green pepper, diced
1 small onion, sliced
20 ounces diced canned tomatoes, drained
1 can (4 ounces) green chiles
1/2 cup sour cream
1/2 cup mayonnaise
8 ounces sharp cheddar cheese, shredded
Instructions
- Preheat oven to 350°F. Grease a 9×13-inch casserole dish.
- In a large bowl, combine water and biscuit crust. Give it one minute to sit and thicken up a little.
- Spread the biscuit dough into the bottom of the prepared 9×13-inch casserole dish.
-
In a large skillet, brown ground beef over medium-high heat until browned. Stir in taco seasoning and add water according to directions on taco seasoning. (usually 1/4 to 1/2 cup of water). Spread the meat mixture on top of the biscuit layer.
-
Drain the canned tomatoes and spread the tomatoes on top of the ground beef.
-
In the same skillet, cook the green pepper and sliced onions until softened – about 5 minutes. Sprinkle on top of tomatoes and ground beef mixture, followed by the can of green chiles.
-
In a small bowl, combine sour cream, mayonnaise and 1/2 of the shredded cheese. Spread on top of the beef mixture.
- Top with remaining cheese and bake in 350°F oven for 30 minutes. Let rest five minutes before serving.
Notes
Storage Instructions: Cool casserole, then wrap casserole dish with plastic wrap, or carefuly transfer to an airtight container. Refrigerate for up to three days.
Reheating Instructions: Reheat leftover casserole by cooking in 350°F oven until heated through. This should take about 20 minutes.
Freezing Instructions: This casserole freezes and reheats well. Cook casserole completely, then cool. Wap entire casserole dish in plastic wrap followed by a layer of aluminum foil. Freeze for up to three months. Thaw completely in the refrigerator, then reheat in 350°F oven until heated though.
- Prep Time: 15 minutes
- Cook Time: 30 minutes
- Category: Dinner
- Method: Oven Baked
- Cuisine: American
Nutrition
- Serving Size: 1 generous helping
- Calories: 722
- Sugar: 13.3 g
- Sodium: 1293.3 mg
- Fat: 35.4 g
- Saturated Fat: 13.6 g
- Trans Fat: 0.7 g
- Carbohydrates: 49.5 g
- Fiber: 3.2 g
- Protein: 49.6 g
- Cholesterol: 143.3 mg
Totally love this casserole. So delicious. Thanks for sharing
This is a blast from the past! I remember having it when I was little. I can’t wait to make it for my kids. Thanks for the recipe!
You’re welcome Kate! I hop you enjoy this casserole recipe 🙂
This has comfort food written all over it and it did not disappoint! Thank you so much for this yummy recipe!
You’re so welcome! Enjoy!!
So many delicious flavors in one recipe! …and it’s the perfect size for a crowd. Yum!
This looks so good! I love a good casserole for a quick weeknight family meal! This might be my new go-to!
Another amazing weeknight casserole from Shesnotcookin! So easy for leftovers and we loved the Bisquick layer!! Who can resist a John Wayne casserole!
This is such a tasty, easy casserole to make, and that creamy, cheesy topping makes it SOOOO good! Another winner dinner!
Thanks so much Eliza! Enjoy 🙂
I wonder what this would be like if you replaced the sauce with Manwich sauce. Maybe add some corn.
I haven’t tried that but it sounds delicious!
My husband made your casserole while he was off of work due to a stroke. He had to be off for one year due to the fact he is a truck driver. I put Pintrest on his phone and he started checking out recipes because he got tired of eating the same things all the time and we have a lot of picky people in my household. I would come home from work and dinner would always be ready or almost done. This meal was so good I swiped it off of his Pintrest page.
Thrilled to hear that you enjoyed this casserole! Thanks so much for sharing your story and take care!
I have made it twice now and it’s perfect. My family can’t make one complaint about anything in this casserole, they truly love it that much!
That’s so great to hear! Thanks so much for taking the time to share your feedback 🙂
Made this recipe for my 22 yr old daughter. This was the only school food she liked when she was there. She said it was spot on and made her feel like a kid again. I did half the recipe since it’s just the two of us and it was perfect for us for two dinners!
That’s fantastic! So happy to hear that you enjoyed this recipe!
Can I substitute the green pepper and diced tomatoes with 20 of rotel? Close enough, right?
Yes, that should work 🙂